Prof. Dr. Lars E. French

Klinik für Dermatologie & Allergologie I

Klinik Thalkirchner Straße

Werdegang

Seit November 2018
Ärztlicher Direktor der Dermatologie I in der Klinik Thalkirchner Straße

2006 - 2018
Klinikdirektor der Dermatologischen Klinik, Universitätsspital Zürich (Schweiz) 

2003-2006
Associate Professor, Dermatologie, Universitätsspital Genf  

2003 - 2006
Louis-Jeantet Professur für Medizin, Fakultät für Medizin, Universität Genf  

1999-2000
Visiting Clinical and Research Fellow, Department of Dermatology, University of Pennsylvania Health System, Philadelphia, USA (Prof. J. Stanley, Prof. A.H. Rook)  

1998
Privatdozent, universität Genf

1993 - 1997
Resident and Fellow, Dermatology Department, Universitätsspital, Genf, Schweiz

1993
Promotion

1990 - 1993
Research Fellow in cell and molecular biology, Geneva University Medical Center, Genf, Schweiz

1988
Diplom für Medizin, Fakultät für Medizin, Universität Genf
Facharztdiplom Dermatologie (FMH); Privatdozent Universität Genf

Wissenschaftliche Tätigkeit

Prof. Dr. French leitete in der Schweiz eine eigene Forschungsgruppe. Schwerpunkte seiner wisschenschaftlichen Forschungstätigkeit waren die angeborene Immunität (Inflammasom und IL-1 Familie) und deren Rolle bei entzündlichen Hautkrankheiten, die Tumorimmunologie und die Pathogenese von schweren kutanen Arzneimittelallergien.

Auszeichnungen

  • 2012 Otto Naegeli‐Preis  
  • 2000 Pfizer Prize for Clinical Research in Immunology/Rheumatology
  • 1999 Leenaards Foundation Prize for the Encouragement of Scientific Research
  • 1998 Prix Claude Perrier de la Fondation pour la Promotion de l’Enseignement et de la Recherche en Pharmacothérapie
  • 1997 ‐ 2002 „SCORE A“, career development award (Swiss Clinicians Opting for Research/Swiss National Science Foundation)
  • 1995 Roche Prize for Dermatological Research  

Mitgliedschaften

  • seit 2010 Vize‐Präsident Schweizerische Gesellschaft für Dermatologie und Venerologie (SGDV)  
  • seit 2008 Vorstandsmitglied, European Dermatology Forum (EDF) 
  • seit 2008 Mitglied der Deutschen Akademie der Naturforscher Leopoldina  
  • 2004 ‐ 2005 Präsident, European Society for Dermatological Research (ESDR)  
  • 1997 ‐ 2005 Vorstandsmitglied, European Society for Dermatological Research (ESDR)  

Publikationen

Prof. Dr. Lars E. French hat ca. 300 Fachartikel veröffentlicht. Alle Publikationen können Sie hier einsehen.

Hier finden Sie einen Auszug seiner Publikationen von 2017 bis heute.

  1. Topical resiquimod dosing regimens in patients with multiple actinic keratosis: a multi-centre, partly placebo-controlled, double-blind, clinical trial. Stockfleth E, Hofbauer GFL, Reinhold U, Popp G, Hengge UR, Szeimies RM, Brüning H, Anliker M, Hunger T, Dummer R, Ulrich C, Kenzelmann R, Surber C, French LE. Br J Dermatol. 2018 Sep 1. doi: 10.1111/bjd.17124. 
  2. Mechanisms Underlying the Clinical Effects of Apremilast for Psoriasis. Pincelli C, Schafer PH, French LE, Augustin M, Krueger JG. J Drugs Dermatol. 2018 Aug 1;17(8):835-840.
  3. Genome editing of human primary keratinocytes by CRISPR/Cas9 reveals an essential role of the NLRP1 inflammasome in UVB sensing. Fenini G, Grossi S, Contassot E, Biedermann T, Reichmann E, French LE, Beer HD. J Invest Dermatol. 2018 Aug 7. pii: S0022-202X(18)32462-X. doi: 10.1016/j.jid.2018.07.016. 
  4. Inflammation: A Contributor to Depressive Comorbidity in Inflammatory Skin Disease. Farzanfar D, Dowlati Y, French LE, Lowes MA, Alavi A. Skin Pharmacol Physiol. 2018;31(5):246-251. doi: 10.1159/000490002. 
  5. Cytokine Release Syndrome During Sequential Treatment With Immune Checkpoint Inhibitors and Kinase Inhibitors for Metastatic Melanoma. Dimitriou F, Matter AV, Mangana J, Urosevic-Maiwald M, Micaletto S, Braun RP, French LE, Dummer R. J Immunother. 2018 Jun 22. doi: 10.1097/CJI.0000000000000236. 
  6. PD-L1 expression is an independent predictor of favorable outcome in patients with localized esophageal adenocarcinoma. Kollmann D, Ignatova D, Jedamzik J, Chang YT, Jomrich G, Baierl A, Kazakov D, Michal M, French LE, Hoetzenecker W, Schatton T, Asari R, Preusser M, Gnant M, Guenova E, Schoppmann SF. Oncoimmunology. 2018 Mar 13;7(6):e1435226. doi: 10.1080/2162402X.2018.1435226. eCollection 2018.
  7. Aggressive Rare T-cell Lymphomas with Manifestation in the Skin: A Monocentric Cross-sectional Case Study. Brüggen MC, Kerl K, Haralambieva E, Schanz U, Chang YT, Ignatova D, Dummer R, Cozzio A, Hoetzenecker W, French LE, Guenova E. Acta Derm Venereol. 2018 Apr 24. doi: 10.2340/00015555-2950. [Epub ahead of print]
  8. CARD14 Gain-of-Function Mutation Alone Is Sufficient to Drive IL-23/IL-17-Mediated Psoriasiform Skin Inflammation In Vivo. Mellett M, Meier B, Mohanan D, Schairer R, Cheng P, Satoh TK, Kiefer B, Ospelt C, Nobbe S, Thome M, Contassot E, French LE. J Invest Dermatol. 2018 Sep;138(9):2010-2023. doi: 10.1016/j.jid.2018.03.1525. Epub 2018 Apr 22.
  9. Autoinflammation behind the curtain. Navarini AA, French LE. Br J Dermatol. 2018 Mar;178(3):581-582. doi: 10.1111/bjd.16258. No abstract available.
  10. Survival of Second-Line Biologics in Psoriasis: The British BADBIR Registry Data Informs Daily Practice. Navarini AA, French LE. J Invest Dermatol. 2018 Apr;138(4):726-728. doi: 10.1016/j.jid.2018.02.008.
  11. Methadone-Not a magic bullet in melanoma therapy. Brüggen MC, Mangana J, Irmisch A, French LE, Levesque MP, Cheng PF, Dummer R. Exp Dermatol. 2018 Jun;27(6):694-696. doi: 10.1111/exd.13543.
  12. The Crosstalk between Nrf2 and Inflammasomes. Hennig P, Garstkiewicz M, Grossi S, Di Filippo M, French LE, Beer HD. Int J Mol Sci. 2018 Feb 13;19(2). pii: E562. doi: 10.3390/ijms19020562. Review.
  13. Propionibacterium acnes Strains Differentially Regulate the Fate of Th17 Responses in the Skin. Contassot E, French LE. J Invest Dermatol. 2018 Feb;138(2):251-253. doi: 10.1016/j.jid.2017.09.041.
  14. Expression of inflammasome proteins and inflammasome activation occurs in human, but not in murine keratinocytes. Sand J, Haertel E, Biedermann T, Contassot E, Reichmann E, French LE, Werner S, Beer HD. Cell Death Dis. 2018 Jan 18;9(2):24. doi: 10.1038/s41419-017-0009-4.
  15. TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis. Conrad C, Di Domizio J, Mylonas A, Belkhodja C, Demaria O, Navarini AA, Lapointe AK, French LE, Vernez M, Gilliet M. Nat Commun. 2018 Jan 2;9(1):25. doi: 10.1038/s41467-017-02466-4.
  16. The p38 Mitogen-Activated Protein Kinase Critically Regulates Human Keratinocyte Inflammasome Activation. Fenini G, Grossi S, Gehrke S, Beer HD, Satoh TK, Contassot E, French LE. J Invest Dermatol. 2018 Jun;138(6):1380-1390. doi: 10.1016/j.jid.2017.10.037. Epub 2017 Dec 26.
  17. Evaluation of the National Swiss Skin Cancer Screening Campaign 2013: Do We Do the Right Thing. Braun RP, Ulrich K, Hunger R, Gaide O, Arnold A, Merat R, Dummer R, Hafner J, French LE, Cozzio A. Dermatology. 2017;233(5):404-409. doi: 10.1159/000484946. Epub 2017 Dec 14.
  18. Radiotherapy-induced reactivation of neurotrophic human herpes viruses: Overview and management. Ramirez-Fort MK, Zeng J, Feily A, Ramirez-Pacheco LA, Jenrette JM, Mayhew DL, Syed T, Cooper SL, Linden C, Graybill WS, French LE, Lange CS. J Clin Virol. 2018 Jan;98:18-27. doi: 10.1016/j.jcv.2017.11.004. Epub 2017 Nov 22. Review.
  19. Individualized treatment approaches for Langerhans cell histiocytosis. Roider E, Signer C, Fehrenbacher B, Metzler G, Schaller M, Kamarachev J, Kerl K, Balabanov S, Jochum W, Hoetzenecker W, Cozzio A, French LE, Dummer R, Guenova E. Br J Dermatol. 2018 Jun;178(6):1423-1424. doi: 10.1111/bjd.16171. Epub 2018 Mar 23. No abstract available.
  20. Clinical Disease Patterns in a Regional Swiss Cohort of 34 Pyoderma Gangrenosum Patients. Kolios AGA, Gübeli A, Meier B, Maul JT, Kündig T, Nilsson J, Hafner J, Guenova E, Kerl K, Anliker M, Kempf W, Navarini AA, French LE, Cozzio A. Dermatology. 2017;233(4):268-276. doi: 10.1159/000481432. Epub 2017 Nov 7.
  21. Successful treatment of SAPHO syndrome with apremilast. Adamo S, Nilsson J, Krebs A, Steiner U, Cozzio A, French LE, Kolios AGA. Br J Dermatol. 2017 Oct 16. doi: 10.1111/bjd.16071. [Epub ahead of print]
  22. TNFα and IL-17A are differentially expressed in psoriasis-like vs eczema-like drug reactions to TNFα antagonists. Deubelbeiss C, Kolios AGA, Anzengruber F, French LE, Yawalkar N, Kempf W, Kerl K, Meier B, Navarini AA. J Cutan Pathol. 2018 Jan;45(1):23-28. doi: 10.1111/cup.13055. Epub 2017 Nov 22.
  23. Comparison of pyoderma gangrenosum and Martorell hypertensive ischaemic leg ulcer in a Swiss cohort. Kolios AGA, Hafner J, Luder C, Guenova E, Kerl K, Kempf W, Nilsson J, French LE, Cozzio A. Br J Dermatol. 2018 Feb;178(2):e125-e126. doi: 10.1111/bjd.15901. Epub 2018 Jan 7. No abstract available.
  24. A case of tinea incognita and differential diagnosis of figurate erythema. Maul JT, Maier PW, Anzengruber F, Murer C, Bosshard PP, Kerl K, French LE, Navarini AA. Med Mycol Case Rep. 2017 Jul 3;18:8-11. doi: 10.1016/j.mmcr.2017.07.001. eCollection 2017 Dec.
  25. Drug-Induced Pyoderma Gangrenosum: A Review. Wang JY, French LE, Shear NH, Amiri A, Alavi A. Am J Clin Dermatol. 2018 Feb;19(1):67-77. doi: 10.1007/s40257-017-0308-7. Review.
  26. Cutaneous Corynebacterium Infection Presenting with Disseminated Skin Nodules and Ulceration. Kolios AGA, Cozzio A, Zinkernagel AS, French LE, Kündig TM. Case Rep Dermatol. 2017 May 16;9(2):8-12. doi: 10.1159/000476054. eCollection 2017 May-Aug.
  27. Angioimmunoblastic T-Cell Lymphoma Mimicking Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS Syndrome). Mangana J, Guenova E, Kerl K, Urosevic-Maiwald M, Amann VC, Bayard C, Dummer R, French LE. Case Rep Dermatol. 2017 Mar 21;9(1):74-79. doi: 10.1159/000458752. eCollection 2017 Jan-Apr.
  28. Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases. Fenini G, Contassot E, French LE. Front Pharmacol. 2017 May 22;8:278. doi: 10.3389/fphar.2017.00278. eCollection 2017. Review.
  29. European consensus statement on phenotypes of pustular psoriasis. Navarini AA, Burden AD, Capon F, Mrowietz U, Puig L, Köks S, Kingo K, Smith C, Barker JN; ERASPEN Network. J Eur Acad Dermatol Venereol. 2017 Nov;31(11):1792-1799. doi: 10.1111/jdv.14386. Epub 2017 Aug 29. Review.
  30. Comparison of ixekizumab with ustekinumab in moderate-to-severe psoriasis: 24-week results from IXORA-S, a phase III study. Reich K, Pinter A, Lacour JP, Ferrandiz C, Micali G, French LE, Lomaga M, Dutronc Y, Henneges C, Wilhelm S, Hartz S, Paul C; IXORA-S investigators. Br J Dermatol. 2017 Oct;177(4):1014-1023. doi: 10.1111/bjd.15666. Epub 2017 Jul 19.
  31. Paradoxical ulcerative colitis during adalimumab treatment of psoriasis resolved by switch to ustekinumab. Kolios AGA, Biedermann L, Weber A, Navarini AA, Meier J, Cozzio A, French LE. Br J Dermatol. 2018 Feb;178(2):551-555. doi: 10.1111/bjd.15631. Epub 2017 Nov 28.
  32. Extreme Phenotype of Epidermal Growth Factor Receptor Inhibitor-induced Destructive Folliculitis. Anzengruber F, Meier B, Maul JT, Kerl K, French LE, Navarini AA. Int J Trichology. 2016 Oct-Dec;8(4):176-179. doi: 10.4103/0974-7753.203174.
  33. CYFIP1 is directly controlled by NOTCH1 and down-regulated in cutaneous squamous cell carcinoma. Dziunycz PJ, Neu J, Lefort K, Djerbi N, Freiberger SN, Iotzova-Weiss G, French LE, Dotto GP, Hofbauer GF. PLoS One. 2017 Apr 14;12(4):e0173000. doi: 10.1371/journal.pone.0173000. eCollection 2017.
  34. Successful treatment with imatinib after nilotinib and ipilimumab in a c-kit-mutated advanced melanoma patient: a case report. Murer C, Kränzlin-Stieger P, French LE, Dummer R, Goldinger SM. Melanoma Res. 2017 Aug;27(4):396-398. doi: 10.1097/CMR.0000000000000358.
  35. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Standard Reporting and Evaluation Guidelines: Results of a National Institutes of Health Working Group. Maverakis E, Wang EA, Shinkai K, Mahasirimongkol S, Margolis DJ, Avigan M, Chung WH, Goldman J, La Grenade L, Pirmohamed M, Shear NH, Tassaeeyakul W, Hoetzenecker W, Klaewsongkram J, Rerkpattanapipat T, Manuyakorn W, Yasuda SU, Sharon VR, Sukhov A, Micheletti R, Struewing J, French LE, Cheng MY. JAMA Dermatol. 2017 Jun 1;153(6):587-592. doi: 10.1001/jamadermatol.2017.0160.
  36. Opposing effects of Nrf2 and Nrf2-activating compounds on the NLRP3 inflammasome independent of Nrf2-mediated gene expression. Garstkiewicz M, Strittmatter GE, Grossi S, Sand J, Fenini G, Werner S, French LE, Beer HD. Eur J Immunol. 2017 May;47(5):806-817. doi: 10.1002/eji.201646665. Epub 2017 Apr 10.
  37. Pyoderma Gangrenosum: An Update on Pathophysiology, Diagnosis and Treatment. Alavi A, French LE, Davis MD, Brassard A, Kirsner RS. Am J Clin Dermatol. 2017 Jun;18(3):355-372. doi: 10.1007/s40257-017-0251-7. Review.
  38. A Report of Two Cases of Solid Facial Edema in Acne. Kuhn-Régnier S, Mangana J, Kerl K, Kamarachev J, French LE, Cozzio A, Navarini AA. Dermatol Ther (Heidelb). 2017 Mar;7(1):167-174. doi: 10.1007/s13555-017-0173-6. Epub 2017 Feb 6.